Correlation Between Serum CaN,NFATc1 Levels and Immunoglobulin Treatment Response in Children with Kawasaki Disease
Objective To investigate the correlation between serum levels of calcineurin(CaN),nuclear factor of activated T cells c1(NFATc1)and immunoglobulin(IVIG)treatment responsiveness in children with Kawasaki disease,in order to provide theoretical reference for clinical improvement of treatment efficacy.Methods A prospective cohort study was conducted to select 100 children with Kawasaki disease from Pingdingshan First People's Hospital from January 2018 to January 2023.The levels of serum CaN and NFATc1 were detected at admission,and the general data of the children were collected.According to the response to IVIG treatment,the children were divided into IVIG sensitive group and IVIG non-responsive group.Serum CaN and NFATc1 levels and general data were compared between the two groups.The relationship between serum CaN and NFATc1 levels and IVIG treatment response was tested by point two column correlation,and the effect of the two on IVIG treatment response was tested by logistic regression.Results Among the 100 patients,20 were unresponsive to IVIG treatment,accounting for 20％(20/100).The levels of serum CaN,NFATc1 and C-reactive protein(CRP)in the IVIG non-responsive group were higher than those in the IVIG sensitive group at admission(P＜0.05).The point two column correlation test showed a positive correlation between serum CaN and NFATc1 levels and no response to IVIG treatment in children with Kawasaki disease(r＞0,P＜0.05).Logistic regression analysis showed that high levels of serum CaN and serum NFATc1 were the influencing factors leading to unresponsiveness to IVIG treatment in children(P＜0.05).Conclusion Children with Kawasaki disease have a higher risk of unresponsiveness after IVIG treatment,and there is a relationship between them and serum CaN and NFATc1.The high expression of both is a contributing factor to the unresponsiveness of IVIG treatment.
Kawasaki diseaseimmunoglobulin therapycalcineurinnuclear factor of activated T cells c1correlation
万方数据
维普
