Relationship Between Preoperative Serum Alkaline Phosphatase,Osteopontin and the Prognosis of Neuroendoscopic Clearance Surgery in Patients with Basal Ganglia Hemorrhage
Objective To analyze the relationship between preoperative serum alkaline phosphatase(ALP)and osteopontin(OPN)and the prognosis of patients with basal ganglia hemorrhage treated with neuroendoscopic clearance surgery,and to evaluate its predictive value for patient prognosis.Methods A retrospective study was conducted to collect data from 65 patients with basal ganglia hemorrhage who underwent minimally invasive hematoma removal surgery under neuroendoscopy at the First People's Hospital of Shangqiu from January 2019 to June 2023.The results of laboratory indicators required for the study were recorded,including preoperative and postoperative serum ALP and OPN levels.The prognosis of patients 1 month after operation was statistically analyzed,and the relationship between preoperative serum ALP and OPN and prognosis in patients with cerebral hemorrhage was analyzed.Results Among the 65 patients with basal ganglia hemorrhage,14 had poor prognosis,accounting for 21.54％.Before and after operation,serum ALP and OPN in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).After point two column correlation analysis,preoperative serum ALP and OPN were positively correlated with poor prognosis in patients with cerebral hemorrhage(r＞0,P＜0.05).The results of drawing receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of preoperative serum ALP and OPN predicting poor prognosis in patients with cerebral hemorrhage was greater than 0.70,and the AUC of combined prediction was greater than 0.80,indicating higher combined predictive value.Conclusion The higher the preoperative ALP and OPN levels in patients with basal ganglia hemorrhage undergoing endoscopic clearance surgery,the greater the likelihood of poor prognosis after treatment.Preoperative ALP and OPN levels can be effective predictors of poor prognosis in patients with basal ganglia hemorrhage undergoing endoscopic clearance surgery.
万方数据
维普
