Effects of Fuzheng Jiedu Decoction in Patients with Colorectal Cancer
Objective To study the effects of Fuzheng Jiedu decoction in patients with colorectal cancer.Methods From January 2020 to October 2022,a total of 96 patients with colorectal cancer admitted to the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine were divided into the chemotherapy group(48 cases)and the Fuzheng Jiedu group(48 cases)by simple random grouping.The chemotherapy group was treated with FOLFOX4 chemotherapy regimen,and the Fuzheng Jiedu group was treated with Fuzheng Jiedu decoction on the basis of the chemotherapy group.Both groups were treated for 18 weeks.The clinical efficacy of the two groups after 18 weeks of treatment was analyzed,and the traditional Chinese medicine syndrome score,functional status,tumor markers,phosphatidylinositol 3 enzyme(PI3K)-seronine protein kinase(PI3 K-Akt)signaling pathway,intestinal flora and quality of life of the two groups were compared before and after 18 weeks of treatment.Results After 18 weeks of treatment,the disease control rate and total remission rate of Fuzheng Jiedu group(68.75％and 54.17％)were higher than those of chemotherapy group(47.92％and 31.25％)(P＜0.05).After 18 weeks of treatment,the scores of primary and secondary symptoms in Fuzheng Jiedu group were lower than those before treatment,and lower than those of chemotherapy group(P＜0.05).The scores of functional status,number of Lactobacillus,Bifidobacterium and future prospect of the two groups were higher than those before treatment,and the Fuzheng Jiedu group was higher than the chemotherapy group(P＜0.05).The levels of serum carcinoembryonic antigen,carbohydrate antigen 199,peripheral blood PI3K mRNA,Akt mRNA,the number of Enterococcus and Escherichia coli,urination and the scores of stool problems and weight loss of the two groups were lower than those before treatment,and the Fuzheng Jiedu group was lower than the chemotherapy group(P＜0.05).Conclusion Fuzheng Jiedu decoction combined with FOLFOX4 chemotherapy regimen could improve the traditional Chinese medicine syndrome and functional status of patients with colorectal cancer,reduce the level of tumor markers,regulate the PI3 K-Akt signaling pathway and intestinal flora,improve the quality of life of patients,and had a good therapeutic effect.
万方数据
维普
