Effect of One-Stage Retrograde Ureteral Lithotripsy and Percutaneous Nephrolithotomy in Patients with Kidney Stones
Objective To compare the effect of one-stage retrograde flexible ureteroscopic lithotripsy(FURL)and percutaneous nephrolithotomy(PCNL)in the treatment of patients with kidney stone(KS).Methods A total of 98 patients with KS in the First Affiliated Hospital of Zhengzhou University from March 2022 to March 2023 were retrospectively collected and divided into two groups according to different surgical protocols.Forty-nine patients receiving one-stage FURL were included in the observation group,and 49 patients receiving PCNL were included in the control group.The perioperative indicators,preoperative and postoperative 2 days renal function[blood urea nitrogen(BUN),urinary kidney injury molecule-1(KIM-1),serum creatinine(Scr)],inflammatory factors[interleukin-1(IL-1),IL-10,C reactive protein(CRP)],stress indicators[corticosteroids(Cor),adrenocorticotropic hormone(ACTH),norepinephrine(NE)],stone clearance rate,and complication rate were compared between the two groups.Results Compared with the control group,the amount of intraoperative bleeding in the observation group was lower,and the operation time and hospitalization time were shorter(P＜0.05).Compared with pre-operation,serum BUN,KIM-1,and Scr levels increased in both groups 2 days after surgery,but the observation group was lower than the control group(P＜0.05).Compared with pre-operation,serum IL-1,IL-10,and CRP levels increased in both groups 2 days after surgery,but the observation group was lower than the control group(P＜0.05).Compared with pre-operation,serum Cor,ACTH,and NE levels increased in both groups 2 days after surgery,but the observation group was lower than the control group(P＜0.05).There was no significant difference in stone clearance between the two groups(P＞0.05).The complication rate of observation group[2.04％(1/49)]was lower than that of control group[16.33％(8/49)](P＜0.05).Conclusion One-stage retrograde FURL and PCNL have the same effect on stone removal in KS patients,but the former can further reduce intraoperative blood loss,shorten the time spent in surgery and hospitalization,reduce the risk of complications,and reduce postoperative stress and inflammatory reaction,and have less damage to renal function.
one-stage retrograde ureteral soft lithotripsykidney stonestress responsepercutaneous nephrolithotomyintraoperative blood loss
万方数据
维普
