Evaluation Value and Clinical Significance of Dynamic Monitoring of Serum PCT,SAA and IgE in ICU Sepsis in Children with Septic Acute Kidney Injury
Objective To observe the evaluation value and clinical significance of dynamic levels of serum procalcitonin(PCT),amyloid A(SAA),and immunoglobulin E(IgE)in evaluating the severity of acute kidney injury(AKI)in children with sepsis in the ICU.Methods A retrospective selection was conducted on 180 children with sepsis admitted to the intensive care unit(ICU)of Henan Children's Hospital from March 2022 to March 2023.According to the occurrence of AKI,they were divided into AKI group(112 cases)and non AKI group(68 cases).General clinical data(gender,age,underlying disease,site of infection,acute physiology and chronic health Ⅱ(APACHE Ⅱ)score,sequential organ failure assessment(SOFA)score of the two groups were compared,serum PCT,SAA,IgE levels of the two groups were compared,and the influencing factors of AKI in sepsis in children were analyzed.ROC analysis of the combined detection of serum PCT,SAA and IgE levels in the prediction of AKI.Results The scores of APACHE Ⅱ and SOFA in AKI group were higher than those in non-AKI group(P＜0.05).Comparison of serum PCT,SAA and IgE levels between the two groups at different time points,AKI group was higher than non-AKI group,the 1st day after admission＞the 3rd day after admission＞the 7th day after admission,and each index level was positively correlated with APACHE Ⅱ score and SOFA score(P＜0.05).APACHE Ⅱ score,SOFA score,serum PCT,SAA and IgE levels on the 7th day after admission were the risk factors for AKI in sepsis in children(OR＞1,P＜0.05),and the AUC of serum indexes combined to predict AKI in sepsis in children on the 7th day after admission was 0.859.Conclusion Serum PCT,SAA and IgE levels are closely related to the severity of AKI,and the combined detection of all indicators has high predictive value for the occurrence of AKI in sepsis in children,and can be used as an effective indicator for clinical judgment and prediction of AKI.
dynamic monitoringprocalcitoninserum amyloid A proteinimmunoglobulin Eseptic acute kidney injury
万方数据
维普
