Effect of Lactate Dehydrogenase/Albumin on Bortezomib Chemoresistance in Patients with Multiple Myeloma
Objective To investigate the effect of lactate dehydrogenase(LDH)/albumin(ALB)on bortezomib chemoresistance in patients with multiple myeloma(MM).Methods The clinical data of 124 MM patients admitted to the First People's Hospital of Shangqiu from May 2021 to May 2023 were retrospectively analyzed.All patients have received 4 cycles of bortezomib plus dexamethasone chemotherapy.According to the MM efficacy evaluation criteria,the chemotherapy resistance was evaluated.The data of patients with drug resistance were included in the occurrence group(16 cases),and the data of patients without drug resistance were included in the non occurrence group(108 cases).General data such as gender,Durie-Salmon stage,and MM course were compared between the two groups.LDH,ALB and other laboratory indexes were compared before chemotherapy,and LDH/ALB value was calculated.The effect of LDH/ALB on bortezomib chemoresistance in MM patients was investigated by receiver operating characteristic(ROC)curve and point binary correlation analysis.Results The proportion of stage Ⅲ,LDH,LDH/ALB in the occurrence group were higher than those in the non occurrence group,and ALB was lower than those in the non occurrence group,with a statistical significant difference(P＜0.05).The point binary correlation analysis showed that LDH/ALB,LDH,ALB were related to the occurrence of bortezomib resistance in MM patients(P＜0.05).The ROC was drawn,and the results showed that the area under the curve values of LDH,ALB,LDH/ALB to predict the occurrence of bortezomib chemotherapy resistance in MM patients were 0.791,0.780,0.849,respectively.LDH/ALB had the highest predictive value.Conclusion LDH/ALB can affect the chemoresistance of MM patients to bortezomib.The higher the value,the higher the probability of chemoresistance.
万方数据
维普
