Predictive Value of LDL-C/HDL-C for the Prognosis of Interventional Therapy in Patients with Acute Non-ST-Segment Elevation Myocardial Infarction
Objective To explore the predictive value of low-density lipoprotein cholesterol(LDL-C)/high-density lipoprotein cholesterol(HDL-C)on the prognosis of interventional therapy in patients with acute non-ST-segment elevation myocardial infarction(NSTEMI).Methods A total of 105 NSTEMI patients admitted to the hospital from June 2021 to June 2022 who underwent percutaneous coronary intervention were selected as the study subjects.Baseline data were recorded at admission,blood samples were collected,serum LDL-C and HDL-C levels were measured,and the LDL-C/HDL-C ratio was calculated.After intervention therapy,a one-year follow-up was conducted to observe the prognosis of patients.Logistic regression analysis was used to analyze the risk factors for intervention therapy prognosis in NSTEMI patients,and receiver operating characteristic(ROC)curves were drawn to test the predictive value of LDL-C/HDL-C for intervention therapy prognosis in NSTEMI patients.Results A total of 105 NSTEMI patients were followed up for 1 year after discharge after interventional treatment.There were 25 patients(23.81％)with major adverse cardiovascular events were classified as the poor prognosis group,and 80 patients without major adverse cardiovascular events were classified as the good prognosis group.The serum levels of cTnT,LDL-C,LDL-C and HDL-C in the poor prognosis group were higher than those in the good prognosis group,while the HDL-C level was lower than that in the good prognosis group(P＜0.05).Logistic regression analysis showed that cTnT,LDL-C,LDL-C/HDL-C were risk factors for poor prognosis after intervention in NSTEMI patients(OR＞1,P＜0.05),while HDL-C was a protective factor for poor prognosis after intervention in NSTEMI patients(OR＜1,P＜0.05).The area under the curve(AUC)of LDL-C,HDL-C and LDL-C/HDL-C predicting the prognosis of NSTEMI patients after interventional treatment were 0.677,0.795 and 0.808,respectively.Conclusion LDL-C/HDL-C is closely related to the prognosis of NSTEMI patients undergoing interventional therapy,the upregulation of its level can indicate an increased risk of poor prognosis after interventional therapy.
万方数据
维普
