Correlation Between H-FABP,NT-proBNP and Volume Load Status and Prognosis in Patients with Acute Heart Failure
Objective To investigate the evaluation of heart type-fatty acid binding protein(H-FABP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)on volume load status and prognosis in patients with acute heart failure.Methods This study was a prospective study that included 83 elderly patients with acute heart failure admitted to the emergency department of Anyang People's Hospital from January 2021 to January 2022 as the research group.Another 83 individuals undergoing health examinations during the same period were selected as the control group.Based on relative volume balance levels,the 83 patients were divided into overloaded capacity group and non-overloaded capacity group.All discharged patients were followed up for three months,with those who died categorized as the death group and others as the survival group.The differences in H-FABP and NT-proBNP levels between the research group and control group,different volume loads groups along with different prognoses were compared to investigate their correlation with survival status and volume load state.Results The levels of H-FABP and NT-proBNP in the research group were significantly higher than those in the control group(P＜0.001).The levels of H-FABP and NT-proBNP in overloaded capacity patients were significantly higher than those in non-overloaded capacity patients(P＜0.05).The levels of H-FABP and NT-proBNP in deceased patients were significantly higher than those in surviving patients(P＜0.05).Through correlation analysis,it was found that patient mortality is positively correlated with both overload capacity level along with H-FABP and NT-proBNP(P＜0.001).Conclusion H-FABP and NT-proBNP are correlated with the volume load status and prognosis of patients with acute heart failure,which helps in evaluating the severity of acute heart failure and plays a positive role in guiding treatment for patients with poor prognosis.
万方数据
维普
