Therapeutic Effect of High Initial Dose of Salbutamol Valsartan Combined with Sodium Creatine Phosphate in the Treatment of Dilated Cardiomyopathy with Heart Failure
Objective To explore the therapeutic effect of high initial dose of salbutamol valsartan combined with sodium creatine phosphate in the treatment of dilated cardiomyopathy(CM)with heart failure(HF).Methods A total of 100 patients with CM combined with HF admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from February 2021 to February 2023 were selected for the study.They were randomly divided into a control group(50 cases)and an observation group(50 cases)using a random number table method.The control group received low initial dose of salbutamol valsartan combined with sodium creatine phosphate treatment.The observation group received high initial dose of salbutamol valsartan combined with sodium creatine phosphate for treatment.The cardiac function and quality of life before treatment and 1 month after treatment were compared.At the same time,the occurrence of adverse drug reactions in all patients within 1 month of treatment was recorded.Results The levels of cardiac troponin I and N-terminal B-type natriuretic peptide in two groups significantly decreased compared to before treatment,and the observation group was lower than the control group,the left ventricular ejection fraction level increased,and the observation group had a higher level than the control group(P＜0.05).After treatment,both groups of Chinese culture modified minnesota heart failure quality of life score and the World Health Organization quality of life-BREF scores increased,and the observation group had higher scores than the control group(P＜0.05).There was no statistical difference in the incidence of adverse drug reactions between the observation group and the control group(P=0.495).Conclusion The combination of high initial dose of salbutamol valsartan and sodium creatine phosphate in patients with CM combined with HF can promote improvement in cardiac function and improve quality of life,with high application safety.
万方数据
维普
