Clinical Pathology and Molecular Genetic Characteristics of Ovarian Sertoli-Leydig Cell Tumors
Objective To explore the clinicopathological and molecular genetic characteristics of ovarian Sertoli-Leydig cell tumors(SLCT).Methods The clinical and pathological data of 13 cases of SLCT in the First Affiliated Hospital of Zhengzhou University were retrospectively reviewed.Sanger sequencing was used to detect somatic mutations in the hotspots of DICER1 gene(exon 24 and 25).Follow-up data was perfected to investigate the correlation between DICER1 mutations and clinical pathological features of SLCT.Relevant literature was also searched.Results SLCT patients had a median age of 24 years old and were hospitalized after presenting symptoms of menstrual irregularities,pelvic masses,and lower abdominal distension.Microscopically,the tumor could exhibit various patterns,such as tubular,cord-like,and sarcomatoid areas.Immunohistochemistry staining showed positive expression for CR,WT-1,Inhibin-a,SF-1,etc.The follow-up showed a recurrence rate of 30.8％(4/13)in patients.DICER1 gene mutations were detected in 76.9％(10/13)of cases.The DICER1 gene mutations were found to be statistically significant in relation to age differences,while no statistical significance was observed in terms of histological differentiation or tumor recurrence.Cases with heterologous differentiation may have a higher rate of DICER1 mutations.Conclusion SLCT exhibits morphological diversity.A combination of clinical features,immunohistochemistry and DICER1 gene testing is recommended.DICER1 mutation is more common in young patients.However,the further study may be needed to evaluate the relation between DICER1 mutation and histological differentiation,as well as tumor recurrence.
万方数据
维普
