Association Between Anxious and Depressed Mood and Cytokines in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Objective To analyze polysomnography(PSG)markers and cytokine levels in obstructive sleep apnea hypopnea syndrome(OSAHS)patients with anxiety and depression,and investigate the pathogenesis of OSAHS associated with anxiety and depression.Methods A total of 82 OSAHS patients with anxiety and depression(group DA)and 75 patients with simple OSAHS(group S)were collected from February 2020 to December 2022 in the First Affiliated Hospital of Zhengzhou University.PSG,Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA)scores and cytokines were analyzed.Results The apnea hypopnea index(AHI),mean apnea time(Amean),IL-18,IL-6 and TNF-α levels in group DA were higher than those in group S,and the mean blood oxygen saturation(SaO2 mean)and INF-γ levels were lower than those in group S,and the differences were statistically significant(P＜0.05).In group DA,HAMD score was positively correlated with IL-18,TNF-αlevels and AHI(r=0.296,0.250,0.238,P＜0.05),HAMA score was positively correlated with IL-6 level(r=0.295,P＜0.05),and AHI was positively correlated with IL-18 level(r=0.357,P＜0.05).Conclusion OSAHS patients with anxiety and depression have more severe symptoms and abnormal cytokine levels.Cytokine-mediated immune pathway may be related to anxiety and depression in OSASH patients.
万方数据
维普
