Effects of Serum Procalcitonin,D-dimer and NLR Levels on the Severity and Prognosis of Acute Biliary Pancreatitis
Objective To analyze the relationship between the levels of procalcitonin(PCT),D-dimer(D-D)and neutrophil/lymphocyte ratio(NLR)and the severity and prognosis of acute biliary pancreatitis.Methods A total of 82 patients with acute biliary pancreatitis admitted to the Third People's Hospital of Henan Province from May 2019 to March 2023 were selected as the study subjects,and were divided into mild pancreatitis(MAP,24 cases)group,moderate-severe pancreatitis(MSAP,26 cases)and severe pancreatitis(SAP,32 cases)according to the severity of their disease.According to their prognosis,they were divided into poor prognosis group(16 cases)and good prognosis group(66 cases).The levels of PCT,D-D and NLR in different types of patients were compared.Spearman correlation was used to analyze the correlation between PCT,D-D and NLR and the severity and prognosis of acute biliary pancreatitis.Receiver operating characteristic curvewas established to evaluate the value of PCT,D-D,and NLR alone and in combination in differentiating disease and predicting prognosis.Results The levels of PCT,D-D and NLR in three groups were significantly different(P＜0.05),and the levels of PCT,D-D and NLR in SAP group were higher than those in MSAP group and higher than those in MAP group(P＜0.05).Compared with the good prognosis group,the levels of PCT,D-D and NLR in the poor prognosis group were higher(P＜0.05).PCT,D-D and NLR were correlated with the condition and prognosis,positive correlation with the condition and negative correlation with the prognosis(P＜0.05).The areas under the curve of PCT,D-D and NLR were 0.877,0.875,0.868 and 0.932 respectively in the identification of severe pancreatitis,which had certain clinical reference value.The areas under the prognostic curves of PCT,D-D and NLR alone and in combination were 0.703,0.755,0.821 and 0.817,respectively,which had certain clinical reference value.Conclusion The levels of PCT,D-D and NLR are closely related to the severity and prognosis of acute biliary pancreatitis.The levels of PCT,D-D and NLR are relatively higher in severe patients and patients with poor prognosis.The three indexes have certain clinical reference value in differentiating the disease and predicting the prognosis separately and jointly.
acute biliary pancreatitisserum procalcitoninD-dimerneutrophil/lymphocyte ratio
万方数据
维普
