Application Effect of Hyperbaric Oxygen Combined with Nimodipine in Patients Undergoing Intracranial Aneurysm Clipping
Objective To explore the effect of postoperative treatment with hyperoxia and nimodipine in patients with intracranial aneurysm(IA)clipping.Methods A total of 90 patients who underwent IA clipping in Luohe Yuanhui District People's Hospital from January 2018 to January 2023 were selected as the research objects.The selected objects were randomly divided into observation group(45 cases)and control group(45 cases).After operation,the control group was treated with nimodipine,and the observation group was treated with hyperbaric oxygen on the basis of the control group.The indexes of cerebral hemodynamics,neurological impairment the occurrence,prognosis,quality of life,activities of daily living andcerebral vasospasm(CVS)were compared between the two groups.Results On the 14th day after treatment,The mean flow velocity(MFV)and maximum peak systolic velocity(SPV)of middle cerebral artery in the observation group were higher than those in the control group(P＜0.05),while the vascular resistance index(RI)and pulsatility index(PI)were lower than those in the control group(P＜0.05).At the same time,the incidence of CVS was lower than those in the control group(P＜0.05).36-item short form survey(SF-36)score and activity of daily living rating scale(ADL)score were higher than that of the control group(P＜0.05),and the prognosis of Glasgow outcome scale(GOS)was better than that of the control group(P＜0.05).On the 7th and 14th days after treatment,the score of National Institutes of Health stroke scale(NIHSS)in the observation group was lower than that of the control group(P＜0.05).Conclusion Hyperbaric oxygen combined with nimodipine can improve postoperative cerebral blood flow and neurological function with IA clipping,reduce the incidence of cerebral vasospasm,improve the prognosis,and improve the quality of life and ability of daily living.
hyperbaric oxygennimodipineintracranial aneurysm clippingcerebral blood flowneurological function
万方数据
维普
