Diagnostic Value of PET/CT Combined with Serum lncRNA THRIL and miR-98-5p Detection for Benign and Malignant Solitary Pulmonary Nodules
Objective To explore the differential diagnostic value of positron emission tomography and computed tomography(PET/CT)combined with serum long non-coding RNA THRIL(lncRNA THRIL)and microRNA 98-5p(miR-98-5p)detection for benign and malignant solitary pulmonary nodules(SPN).Methods From May 2022 to May 2023,115 SPN patients admitted to Nanyang Central Hospital were collected as the study subjects.Based on the pathological examination results,SPN patients were grouped into a benign group(75 cases)and a malignant group(40 cases),the serum lncRNA THRIL and miR-98-5p expression levels were compared between the two groups.Pearson method was applied to analyze the correlation between serum lncRNA THRIL and miR-98-5p.The consistency Kappa test was applied to compare the consistency of PET/CT,serum lncRNA THRIL,miR-98-5p alone and in combination in the diagnosis of SPN malignancy with pathological results.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of PET/CT combined with serum lncRNA THRIL and miR-98-5p levels for malignant SPN.Results The serum lncRNA THRIL level in the malignant group was higher than that in the benign group,and the miR-98-5p level was lower than that in the benign group(P＜0.05).Pearson analysis showed a negative correlation between lncRNA THRIL and miR-98-5p expression(r=-0.491,P＜0.05),and lncRNA THRIL had a targeted binding site with miR-98-5p.A total of 38 patients with malignant SPN were diagnosed by the combination of PET/CT,serum lncRNA THRIL,and miR-98-5p,the consistency with pathological diagnosis was high,with a Kappa value of 0.729(P＜0.05),the specificity,sensitivity,positive predictive value,negative predictive value and accuracy of the combined diagnosis of malignant SPN were the highest,with 90.67％,95.00％,84.44％,97.14％and 92.17％,respectively.The area under the curve(AUC)of PET/CT,serum lncRNA THRIL,combined miR-98-5p in the diagnosis of malignant SPN was 0.921(95％CI:0.874-0.968),which was superior to their respective individual detection(Z=2.235,2.478,2.444,P＜0.05).Conclusion PET/CT combined with serum lncRNA THRIL and miR-98-5p detection can improve the sensitivity and accuracy in the diagnosis of malignant SPN,and have certain application value in the differential diagnosis of benign and malignant SPN.
solitary pulmonary nodulespositron emission tomography and computed tomographylong non-coding RNA THRILmicro RNA-98-5pdiagnostic value
万方数据
维普
