Diagnostic Value of Serum CYFRA21-1,CA125,CA153 and CEA in the Diagnosis and Prediction of Postoperative Recurrence of Breast Cancer
Objective To explore the diagnostic value of serum C-keratin 19 fragment antigen 21-1(CYFRA21-1),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and carcinoembryonic antigen(CEA)in the diagnosis and prediction of postoperative recurrence of breast cancer.Methods A total of 97 cases of breast cancer patients diagnosed and treated in Pingdingshan First People's Hospital from September 2019 to August 2020 were selected as the research group,followed up for 3 years,and divided into recurrent group(19 cases)and non-recurrent group(78 cases)according to whether there was recurrence after operation,and 50 healthy people in the same period were selected as the control group.The serum levels of CYFRA21-1,CA125,CA153 and CEA were compared between the research group and the control group,and between the recurrent group and the non-recurrent group,and the serum CYFRA was analyzed.Results Serum CYFRA21-1,CA125,CA153 and CEA in the study group were higher than those in the control group(P＜0.05).ROC curve analysis showed that the AUC of serum CYFRA21-1,CA125,CA153,CEA and their combination in the diagnosis of breast cancer were 0.784,0.722,0.754,0.821 and 0.888,respectively,and the sensitivity and specificity at the optimal critical value were CA125 59.8％and 100.0％,CA153 55.37％,100.0％,CEA 58.8％,100.0％,their combination 70.4％,100.0％respectively.Serum CYFRA21-1,CA125,CA153 and CEA in recurrent group were significantly higher than those in non-recurrent group(P＜0.05).ROC curve analysis showed that the AUC of serum CYFRA21-1,CA125,CA153 and CEA in predicting postoperative recurrence of breast cancer were 0.843,0.862,0.825,0.731 and 0.914,respectively.At the optimal cut-off value,the sensitivity and specificity were 68.4％and 100％for CA125,73.7％and 74.4％for CA153,57.9％and 88.5％for CEA,and 78.9％and 96.2％for the combination of the four indexes.Conclusion The combination of serum CYFRA21-1,CA125,CA153 and CEA has high diagnostic and predictive value for the diagnosis and postoperative recurrence of breast cancer.
万方数据
维普
