Value of Peripheral Blood Cell Count-Derived Ratio and Lymphocyte Subset for Assessment of Disease Activity in Patients with Rheumatoid Arthritis
Objective To explore the value of peripheral blood cell count-derived ratio and lymphocyte subset in the assessment of disease activity in patients with rheumatoid arthritis(RA)and interstitial lung disease(ILD).Methods General data,peripheral blood cell count-derived ratio,and lymphocytes subsets composition of 50 RA patients hospitalized from June to December 2020 were collected.According to the disease activity score of 28 joints(DAS 28),they were divided into high disease activity group(DAS 28＞5.1 points)and moderate-low disease activity group(DAS 28≤5.1 points).They were also divided into RA patients without ILD(RA-non-ILD)group and RA patients with ILD(RA-ILD)group on the basis of the presence or absence of ILD.The differences in peripheral blood cell count-derived ratio and lymphocytes subsets composition between the different subgroups were compared.The diagnostic value of peripheral blood cell count-derived ratio and lymphocytes subsets related indicators for assessment of process of rheumatoid arthritis was also evaluated by receiver operating characteristic(ROC)curve.Results Compared with the moderate-low disease activity group,the high disease activity group of RA had a higher platelet-to-lymphocyte ratio(PLR),with significantly lower lymphocyte-to-monocyte ratio,total T lymphocyte ratio,absolute total T lymphocytes counts,CD8+T cell and CD4+T cells counts(P＜0.05).The area under curve(AUC)of PLR was 0.722,with a 95％confidence interval of 0.579-0.865.There was no significant difference in peripheral blood cell count-derived ratio and lymphocytes subsets composition between the RA-non-ILD group and the RA-ILD group(P＞0.05),and the AUC of each indicator ROC was also lower than 0.7.Conclusion PLR may have certain value in distinguishing RA disease activity,while other indicators do not show significant potential in distinguishing RA disease activity or whether ILD is merged.
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