Effect of Smoking on Expression of ERCC1 and RRM1 in Patients with Non-small Cell Lung Cancer
Objective To investigate the effect of smoking on the expression of excision repair cross complement-1(ERCC1)and ribonucleotide reductase subunit M1(RRM1)in non-small cell lung cancer(NSCLC)patients and their relationship with prognosis.Methods A total of 131 patients with stage ⅢB and Ⅳ NSCLC in the First Affiliated Hospital of Henan University of Science and Technology from August 2015 to August 2018 were collected.Patients were divided into two groups based on their smoking history,with 64 cases in the non-smoking group and 67 cases in the smoking group.The expression levels of ERCC1 and RRM1 in each group was detected,their correlation with clinical data of patients,and their impact on patient prognosis was analyzed.Results The proportion of patients with high expression of ERCC1 in the smoking group was higher than that in the non-smoking group(P＜0.05).The expression levels of ERCC1 and RRM1 in two groups were not related to gender,age,tumor size and pathological type(P＞0.05).Patients with a smoking index≥400 showed higher expression of ERCC1(P=0.018).The chemotherapy efficacy of two groups with low expression of ERCC1 and RRM1 was higher than that of patients with high expression(x2=6.194,P=0.013;x2=5.012,P=0.025).Compared with the smoking group,the non-smoking group had a higher chemotherapy efficacy rate(P=0.045),lower 1-year recurrence rate(P=0.001),longer progression free survival(P=0.008)and overall survival(P=0.005).Conclusion Smoking affects the expression of ERCC1,and the higher the smoking index,the higher the expression of ERCC1 in patients.The expression of RRM1 is not related to smoking.The chemotherapy response rate,1-year recurrence rate were lower than those of non-smoking patients,progression-free survival and survival were shorter than those of non-smoking patients.
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