Application of Myocardial Enzymes,sTREM-1 and HMGB1 in Prognosis Evaluation of Patients with Sepsis-Induced Myocardial Dysfunction
Objective To investigate the application of myocardial enzymes,serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and high mobility group box 1(HMGB1)in prognosis evaluation of patients with sepsis-induced myocardial dysfunction(SIMD).Methods A total of 123 patients with SIMD admitted to the First Affiliated Hospital of Henan University from August 2020 to August 2022 were reviewed.According to the prognosis,the patients were divided into death group(38 cases)and survival group(85 cases).General information,aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),serum sTREM-1 and HMGB1 were compared between the two groups.The relationship between above indicators and the prognosis was analyzed.Results The acute physiology and chronic health evalution scoring system(APACHE Ⅱ)score,sequential organ faliure assessment(SOFA)score and the levels of AST,CK and CK-MB in the death group were higher than those in the survival group(P＜0.05),but there was no statistically significant difference in LDH level between the two groups(P＞0.05).Serum sTREM-1 and HMGB1 levels in the death group were higher than those in the survival group(P＜0.05).Cox regression analysis showed that the APACHE Ⅱ score,SOFA score,CK-MB,serum sTREM-1 and HMGB1 were closely related to the prognosis of patients with SIMD(P＜0.05).Conclusion Myocardial enzymes combined with serum sTREM-1 and HMGB1 can help to evaluate the prognosis of patients with SIMD.
sepsismyocardial injurymyocardial enzymeserum soluble triggering receptor expressed on myeloid cells-1high mobility group box 1
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