Efficacy of Different Approaches of Catheter-Directed Thrombolysis Combined with Percutaneous Mechanical Thrombectomy in Patients with Acute Mixed Lowerextremity Deep Venous Thrombosis
Objective To investigate the efficacy of different approaches of catheter-directed thrombolysis(CDT)combined with percutaneous mechanical thrombectomy(PMT)in patients with acute mixed lowerextremity deep venous thrombosis(LDVT)and the impact on their D-D and other indicators and prognosis.Methods A total of 186 patients with acute mixed LDVT were selected from Nanyang First People's Hospital from June 2020 to December 2022 and divided into two groups according to the difference in procedure.One hundred patients in the study group were treated with CDT combined with PMT via the anterior or posterior tibial vein,while 86 patients in the control group were treated with CDT combined with PMT via the popliteal vein.The clinical efficacy and other differences between the two groups were compared.Results The postoperative venous patency rate,thrombus clearance score and swelling reduction rate of the affected calf were obvious higher in the study group than control group,while their total urokinase dose were lower than control group,and hospital stay were shorter than control group(P＜0.05).There was no difference in the incidence of postoperative complications between two groups(P＞0.05).There was no difference in the preoperative test indicators between two groups(P＞0.05),while the postoperative test indicators in both groups were lower than the preoperative ones,more so in the study group(P＜0.05).Three months after surgery,the general comfort questionnaire(GCQ)and post thrombotic syndrome(PTS)score in the study group were better than control group(P＜0.05).Conclusion PMT combined with CDT via anterior or posterior tibial vein access is more effective in treating patients with LDVT without increasing the incidence of postoperative complications,ultimately improving their prognosis and meriting clinical application.
anterior or posterior tibial venous accesslowerextremity deep venous thrombosiscatheter-directed thrombolysispercutaneous mechanical thrombectomyefficacyprognosis
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