Application Effect of Subphreatic Zhuyu Decoction Combined with Paclitaxel,Cisplatin Neoadjuvant Chemotherapy in Patients with Cervical Cancer Syndrome of Qi Stagnation and Blood Stasis
Objective To investigate the application effect of subphreatic Zhuyu decoction combined with paclitaxel,cisplatin neoadjuvant chemotherapy in patients with cervical cancer syndrome of Qi stagnation and blood stasis.Methods A total of 68 patients with cervical cancer admitted to the hospital from January 2021 to December 2022 were selected and divided into study group(34 cases)and control group(34 cases)by random number table method.The control group received neoadjuvant chemotherapy with paclitaxel,cisplatin,and the study group received subphreatic Zhuyu decoction on the basis of the control group.TCM syndrome score,clinical efficacy,immune function,tumor markers and toxic and side effects were compared between the two groups.Results After treatment,TCM syndrome score of 2 groups was decreased,and the study group was lower(P＜0.05).The total effective rate of the study group(94.12％)was higher than the control group(70.59％)(P＜0.05).After treatment,the levels of CD3+and CD4+in the study group were increased,while those in the control group were decreased,and the levels of the study group were higher than the control group(P＜0.05).After treatment,the level of CD8+in the study group was decreased,while that in the control group was increased,and the level of the study group was lower than the control group(P＜0.05).After treatment,serum squamous cell carcinoma antigen(SCCA),cytokeratin 19 fragment 21-1(CYFRA21-1)and carcinoembryonic antigen(CEA)levels in 2 groups were decreased,and those in the study group were lower(P＜0.05).There were no statistical differences in the incidence of gastrointestinal reactions,hepatorenal abnormalities and myelosuppression in class Ⅰ to Ⅳ between the two groups(P＞0.05).Conclusion In the treatment of patients with cervical cancer syndrome of Qi stagnation and blood stasis,subphreatic Zhuyu decoction combined with paclitaxel,cisplatin neoadjuvant chemotherapy is effective,which can improve the immune function of patients,reduce the level of tumor markers,and is safe and reliable.
decoction for removing stasis under diaphragmpaclitaxelcisplatinneoadjuvant chemotherapycervical cancersyndrome of Qi stagnation and blood stasisclinical effect
NETL
NSTL
万方数据
