Effect of Hyperbaric Oxygen Combined with Pramipexole Tablets on Parkinson's Disease Dementia
Objective To explore the effect of hyperbaric oxygen combined with pramexole tablets on Parkinson's disease dementia,cognitive function and the improvement of nerve cytokine levels.Methods A total of 76 patients with Parkinson's disease and dementia admitted to the Third People's Hospital of Henan Province from January 2020 to January 2023 were selected for this study.The patients were grouped by random number table method,with 38 cases in each observation group(hyperbaric oxygen combined with pramexole treatment)and control group(pramexole treatment).The total effective rate,cognitive performance,sleep status,nerve cytokines and adverse response incidence were all compared between the two groups.Results The total effective rate of observation group(86.84％)was not significantly different from that of control group(76.32％)(P＞0.05).There was no significant difference in the scores of cognitive function indexes between the two groups before intervention(P＞0.05).After 6 weeks of intervention,the scores of cognitive function of symptoms in both groups decreased,and the observation group was lower than the control group(P＜0.05).There was no significant difference in the levels of nerve cytokines between the two groups before intervention(P＞0.05).After intervention,the levels of nerve cytokines increased,and the observation group was higher than the control group(P＜0.05).There was no significant difference in sleep quality scores between the two groups before intervention(P＞0.05),and sleep quality scores of the two groups decreased after intervention,and the observation group was lower than the control group(P＜0.05).There was no difference in the total incidence of adverse reactions between the observation group(13.16％)and the control group(7.89％)(P＞0.05).Conclusion Hyperbaric oxygen combined with pramipexole tablets is safe and effective in the treatment of Parkinson's disease dementia,which can improve cognitive function and sleep quality of patients,and enhance the level of nerve cytokines.
万方数据
维普
