Correlation Between Salivary SIgA,Pepsin and Fractional Exhaled Nitric Oxide Levels and Refractory Cough in Patients with Gastroesophageal Reflux Disease
Objective To analyze the relationship between salivary secretory immunoglobulin A(SIgA),pepsin and fractional exhaled nitric oxide(FeNO)levels and the occurrence of refractory cough in patients with gastroesophageal reflux disease(GERD).Methods GERD patients treated in Shangqiu Municipal Hospital from September 2021 to August 2022 were selected and divided into GERD group and GERD combined with refractory cough group based on their condition.Data on patients'DeMeester score,number of reflux cycles,and longest reflux time were collected.Salivary SIgA and gastric protein levels were measured by enzyme-linked immunosorbent assay(ELISA),and FeNO levels were analyzed by NO analyzer.The diagnostic value of salivary SIgA,pepsin and FeNO levels in GERD patients with refractory cough was analyzed by receiver operating characteristic(ROC)of subjects.The influencing factors of GERD complicated with refractory cough was analyzed through logistic analysis.Results Compared with GERD group,DeMeester score,longest reflux time,salivary pepsin and FeNO levels in GERD group with refractory cough increased,and salivary SIgA level decreased(P＜0.05).Saliva SIgA,pepsin,and FeNO predicted the area under the curve of whether GERD patients had refractory cough or not,respectively 0.660(sensitivity 87.1％,specificity 42.9％),0.792(sensitivity 74.2％,specificity 83.7％),0.898(sensitivity 90.3％,specificity 87.8％).Salivary SIgA was a protective factor for GERD patients with refractory cough(OR=0.897,P＜0.05),and salivary pepsin and FeNO were risk factors for GERD patients with refractory cough(OR=1.072,1.297,P＜0.05).Conclusion The decrease of salivary SIgA level and the increase of salivary pepsin and FeNO levels were related to GERD complicated with refractory cough.
万方数据
维普
