Relationship Between Erythrocyte Sedimentation Rate and the Treatment Effect of Pregabalin in Patients with Postherpetic Neuralgia
Objective To analyze the relationship between erythrocyte sedimentation rate and the therapeutic effect of pregabalin in patients with postherpetic neuralgia(PHN),so as to provide empirical guidance for improving the therapeutic effect of PHN patients.Methods The PHN patients treated in Zhumadian Central Hospital from June 2021 to April 2023 were included as the research objects.The patients were given 75 mg pregabalin twice a day for 14 days.Before treatment,the erythrocyte sedimentation rate,C-reactive protein,interleukin-6 and other indicators were detected.After 14 days of treatment,the therapeutic effect was determined.The relationship between erythrocyte sedimentation rate and the therapeutic effect of pregabalin in PHN patients was analyzed.Results A total of 126 PHN patients were included in this study,and 6 were excluded during the treatment period.In the end,a total of 120 patients entered this study.The total effective rate of pregabalin in 120 patients was 81.67％(98/120).The C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate in the ineffective group were higher than those in the effective group,with statistical significant differences(P＜0.05).Logistic regression analysis showed that the increase of C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate were the risk factors for the ineffective treatment of pregabalin in PHN patients(OR＞1,P＜0.05).The receiver operating characteristic curve of the subjects was drawn.The results showed that C-reactive protein,interleukin-6,white blood cell count and erythrocyte sedimentation rate had certain predictive value for the treatment effect of pregabalin in PHN patients,and erythrocyte sedimentation rate had the highest predictive value.Conclusion Erythrocyte sedimentation rate is closely related to the therapeutic effect of pregabalin in PHN patients,and detection of erythrocyte sedimentation rate can provide important value for predicting the therapeutic effect of pregabalin in PHN patients.
postherpetic neuralgiapregabalinerythrocyte sedimentation ratepredictive value
万方数据
维普
