Effect of Warm Acupuncture and Moxibustion Combined with Wutou Mahuang Zhibi Decoction on Dampness-Cold Obstruction Syndrome of Rheumatoid Arthritis
Objective To observe the effect of warm acupuncture and moxibustion combined with Wutou Mahuang Zhibi decoction on dampness-cold obstruction syndrome of rheumatoid arthritis(RA)and its influence on the polarization of macrophages and the level of serum rheumatism related factors.Methods A total of 100 RA patients admitted to Henan Chest Hospital from January 2022 to June 2023 were selected and divided into two groups by random number table method,with 50 patients in each group.The western medicine group was given conventional western medicine treatment,and the traditional Chinese medicine combined group was given warm acupuncture and moxibustion combined with Wutou Mahuang Zhibi decoction on the basis of the western medicine group.The efficacy of the two groups and the incidence of serious complications during treatment were analyzed.The levels of serum related factors such as rheumatoid factor(RF),transforming growth factor-β(TGF-β)and macrophage polarization were detected between the two groups.The differences of RA symptom score,Hospital for Special Surgery(HSS)score and other related scores were evaluated between the two groups.Results The total effective rate of the traditional Chinese medicine combined group was 94.00％,which was higher than 80.00％of the western medication group(P＜0.05).After treatment,RF,B cell chemokine CXC ligand 13(CXCL13)and anti-cyclic citrullinated peptide(CCP)antibody were lower than before in the two groups,and those in the traditional Chinese medicine combined group were lower than those in the western medication group(P＜0.05).After treatment,TGF-β was increased compared before treatment in the two groups,and it was higher in the traditional Chinese medicine combined group than that in the western medication group(P＜0.05).After treatment,the M1 macrophages and M1/M2 in the two groups were lower than those before treatment,and those in the traditional Chinese medicine combined group were lower than those in the western medication group(P＜0.05).Two groups after the treatment of type M2 macrophages from the previous rise,the traditional Chinese medicine combined group was higher than that in the western medication group(P＜0.05).After treatment,the TCM syndrome scores,RA symptom scores and RA disease assessment scale 28(DAS28)scores of the two groups were lower than those before treatment,and the traditional Chinese medicine combined group was lower than those in the western medication group(P＜0.05).After treatment,the HSS scores of the two groups were higher than those before treatment,and the HSS scores of the traditional Chinese medicine combined group were higher than that in the western medication group(P＜0.05).No serious adverse reactions occurred in the 100 patients.Conclusion Warm acupuncture and moxibustion combined with Wutou Mahuang Zhibi decoction can regulate the polarization of macrophages and the expression of RF,TGF-β and other factors to reduce symptoms and improve curative effect.
万方数据
维普
