Application of Bioengineered Lamellar Keratoplasty in Patients Fungal Corneal Ulcer
Objective To investigate the efficacy and safety of bioengineered lamellar keratoplasty in the treatment of fungal corneal ulcer patients.Methods A total of 44 patients with fungal corneal ulcer were selected as the study objects and divided into bioengineering group[20 cases using acellular porcine corneal matrix(APCM)for lamellar corneal transplantation]and human donor group(24 cases using human donor corneal material for lamellar corneal transplantation)according to different corneal materials used.Corneal graft transparency score,best corrected visual acuity(BCVA),corneal epithelial healing time,postoperative complications and recurrence rate were compared between the two groups at different time after surgery.Results At 1,3,6 and 12 months after surgery,the corneal graft transparency score of both groups decreased gradually with the extension of time,and the corneal graft transparency score of the bioengineering group was higher than that of the human donor group at 1,3 and 6 months after surgery(P＜0.05),but there was no statistical significance in the corneal graft transparency score between the two groups at 12 months after surgery(P＞0.05).At 3,6 and 12 months after surgery,BCVA in both groups increased gradually with the extension of time,but BCVA in the bioengineering group at 3,6 and 12 months after surgery was lower than that in the human donor group(P＜0.05).There were no significant differences in the healing time of corneal epithelium,the incidence of postoperative corneal epithelial healing delay,corneal graft rejection,corneal graft dissolution,neovasculation into corneal graft and postoperative recurrence between the two groups(P＞0.05).Conclusion Using APCM as material,lamellar keratoplasty has good clinical effect and high safety in the treatment of fungal corneal ulcer,and can be used as a bioengineered cornea in the treatment of blindness caused by corneal disease.
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