Pathogen Composition and Drug Sensitivity Analysis of Sputum Culture in Patients with Bronchiectasis and Pulmonary Infection
Objective To analyze the composition and drug sensitivity of pathogenic bacteria in sputum cultures of patients with bronchiectasis and pulmonary infection.Methods There were 98 patients with bronchiectasis and pulmonary infection in Xuchang Hospital from February 2021 to February 2023 were selected for sputum culture,pathogen isolation and identification,and drug sensitivity test was conducted by disk diffusion method.Results A total of 103 pathogenic bacteria were isolated from sputum cultures of 98 patients,including 75 Gram negative bacteria(72.82％),25 Gram positive bacteria(24.27％),and 3 fungi(2.91％).Pseudomonas aeruginosa,Escherichia coli and Klebsiella pneumoniae were the most widely distributed in Gram-negative bacteria.Pseudomonas aeruginosa had higher sensitivity to amikacin,tobramycin and piperacillin/tazobactam,and higher resistance to levofloxacin,ciprofloxacin and imipenem.The sensitive rates of Escherichia coli to imipenem,amikacin and piperacillin/tazobactam were higher,and the resistance rates to ceftriaxone,ciprofloxacin and cefotaxime were higher.The sensitivity rates of Klebsiella pneumoniae to imipenem,amikacin and piperacillin/tazobactam were higher,and the resistance rates to cefotaxime,ceftriaxone and ceftazidime were higher.Staphylococcus aureus,Staphylococcus epidermidis and Streptococcus pneumoniae were the most widely distributed in Gram-positive bacteria.Staphylococcus aureus had higher sensitivity to vancomycin,rifampicin and tetracycline,and higher resistance to penicillin,erythromycin and cefuroxime.Streptococcus pneumoniae had high sensitivity to vancomycin,rifampicin and amikacin,and high resistance to penicillin,ciprofloxacin and erythromycin.Staphylococcus epidermidis had high sensitivity to vancomycin,rifampicin and penicillin,and high resistance to erythromycin,tetracycline and cefuroxime.Conclusion The main pathogenic bacteria in sputum cultures of patients with bronchiectasis and pulmonary infection are Gram negative bacteria,and the results of drug sensitivity analysis of different pathogenic bacteria are quite different.Antibacterial drugs should be used reasonably according to the drug sensitivity results in clinical practice.
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