Serum SerpinB1 and YKL-40 Levels in Patients with Gestational Diabetes Mellitus and Their Relationship with Adverse Maternal and Perinatal Outcomes
Objective To investigate changes of serum serine protease inhibitor B1(SerpinB1)and human cartilage glycoprotein-39(YKL-40)levels in patients with gestational diabetes mellitus(GDM)and their relationship with adverse maternal and perinatal outcomes.Methods A total of 95 pregnant women with GDM admitted to the Third Affiliated Hospital of Zhengzhou University from May 2020 to May 2021 and 83 healthy pregnant women who underwent pregnancy examination during the same period were selected as GDM group and healthy group.Serum SerpinB1 and YKL-40 were detected in all pregnant women.All pregnant women and fetuses were followed up for diagnosis of maternal and neonatalt outcomes.The clinical datas,serum SerpinB1 and YKL-40 levels,and adverse maternal outcomes and perinatal outcomes were compared between GDM group and healthy group,and the relationship between serum SerpinB1 and YKL-40 levels and adverse maternal outcomes and perinatal outcomes were logistic analyzed in GDM group.Results The serum levels of SerpinB1 and YKL-40 in GDM group were higher than those in healthy group(P＜0.05).The incidence of adverse maternal outcomes and perinatal outcomes in GDM group were higher than those in healthy group(P＜0.05).There were no significant differences in maternal pre-pregnancy body mass index(BMI),gestational age,education levels between those with adverse maternal outcomes and those without adverse maternal outcomes in GDM group(P＞0.05).GDM patients with maternal adverse outcomes were higher than those without maternal adverse outcomes in age,gestational BMI,proportion of family history of diabetes,proportion of multipara,serum SerpinB1 and YKL-40 levels(P＜0.05).High of age,gestational BMI,family history of diabetes mellitus,multipara,serum SerpinB1 and YKL-40 were all independent risk factors for GDM patients with maternal adverse outcomes(OR=2.190,P=0.023,OR=2.008,P=0.025,OR=2.044,P＜0.001,OR=2.184,P＜0.001,OR=2.132,P=0.010,OR=2.032,P=0.001).There were no significant differences in maternal pre-pregnancy BMI,gestational age,education levels between those with adverse perinatal outcomes and those without adverse perinatal outcomes in GDM group(P＞0.05).GDM patients with adverse perinatal outcomes were higher than those without adverse perinatal outcomes in age,gestational BMI,proportion of family history of diabetes,proportion of multipara,serum SerpinB1 and YKL-40 levels(P＜0.05).High of maternal age,BMI during pregnancy,family history of diabetes,multipara,serum SerpinB1 and YKL-40 levels were independent risk factors for perinatal adverse outcomes in GDM patients(OR=2.223,P=0.014,OR=2.268,P=0.012,OR=2.106,P=0.015,OR=2.153,P=0.007,OR=2.250,P=0.019,OR=2.100,P=0.017).Conclusion The serum levels of SerpinB1 and YKL-40 are higher in GDM group,GDM patients have higher risk of adverse maternal outcomes and perinatal outcomes.Maternal serum SerpinB1 and YKL-40 levels are closely related to adverse maternal and perinatal outcomes in patients with GDM.
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