Expression and Significance of RANTES and STAT 3 in Peripheral Blood of Children with Refractory Mycoplasma Pneumonia
Objective To explore the expression of activated regulated normal T cell expression and secretion factors(RANTES),signal transducers and transcriptional activator 3(STAT3)in the peripheral blood of pediatric Mycoplasma pneumonia and evaluate its predictive value for refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 103 children with RMPP admitted to Henan Children's Hospital Zhengzhou Children's Hospital from August to October 2023 were selected,all of whom received full treatment.The children were divided into general group(MPP group)and RMPP group according to whether they still had persistent fever and aggravation one week after treatment.The expression of RANTES and STAT3 in the two groups were analyzed,and the relevant laboratory indicators of the two groups were analyzed.The general data of the two groups of children were collected,the factors that may induce RMPP were analyzed by univariate and multivariate.Results The levels of RANTES and relative expression of STAT3 mRNA in the RMPP group were higher than those in the MPP group(P＜0.05).The laboratory indicators such as neutrophil count,white blood cell count,C-reactive protein,platelet count,lactate dehydrogenase,and erythrocyte sedimentation rate in the RMPP group were higher than those in the MPP group(P＜0.05).Through univariate and multivariate analysis,it was found that levels of RANTES and STAT3,lactate dehydrogenase,and antibiotic use were all associated with the occurrence of RMPP(P＜0.05).Conclusion Elevated expression levels of RANTES and STAT3 suggest a poor prognosis of Mycoplasma pneumonia in children.
activated to regulate normal T cell expression and secretion factorssignal transductor and transcriptional activator 3refractory Mycoplasma pneumoniae pneumoniarisk factor
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