Application Effect of Different Doses of Aripiprazole in Female Schizophrenia Patients with Hyperprolactinemia Caused by Sulfamethoxide
Objective To compare the clinical efficacy of different doses of aripiprazole in the treatment of hyperprolactinemia in female patients with schizophrenia caused by amisulpiride.Methods According to the random number table method,102 female patients with hyperprolactinemia treated with amisulpride at Rongkang Hospital in Henan Province from March 2020 to September 2022 were divided into a control group(51 cases)and an observation group(51 cases).Both groups maintained the treatment regimen of amisulpiride,while the control group received routine dose of aripiprazole(10 mg per day)and the observation group received low-dose aripiprazole(5 mg per day),both of which continued for 8 weeks.The prolactin(PRL)level,positive and negative symptom scale(PANSS)score,neurocognitive function,inflammation level and adverse reactions were compared between the two groups.Results Compared with before treatment,serum PRL levels,PANSS scores,Wisconsin card sorting test(WCST),and inflammation levels improved in both groups after 8 weeks of treatment(P＜0.05),but there was no statistically difference between the groups(P＞0.05).Compared with the control group,the observation group had lower TESS scores and incidence of adverse reactions(P＜0.05).Conclusion For hyperprolactinemia in female patients with schizophrenia caused by amisulpride,low-dose aripiprazole is as effective as conventional doses,reducing PRL levels,alleviating clinical symptoms of schizophrenia,improving patients'neurocognitive function,and reducing inflammatory reactions.However,low-dose aripiprazole has fewer adverse reactions and higher safety.
NETL
NSTL
万方数据
