Efficacy of Combined Detection of Serum SIRT1,sICAM-1 and PD-L1 in Evaluating the Prognosis of Refractory Diffuse Large B-cell Lymphoma Patients
Objective To explore the prognostic efficacy of combined detection of serum silencing information regulatory factor 1(SIRT1),soluble intercellular adhesion molecule-1(sICAM-1),and programmed cell death-ligand 1(PD-L1)in patients with refractory diffuse large B-cell lymphoma(DLBCL).Methods A total of 84 patients with refractory DLBCL who were treated in the First Affiliated Hospital of Zhengzhou University from January 2022 to October 2023 were selected as the study subjects.According to the disease status one month after treatment,the patients were divided into good prognosis group(57 cases)and poor prognosis group(27 cases).General clinical data of the patients were collected.Enzyme linked immunosorbent assay(ELISA)was used to detect the serum levels of SIRT1,sICAM-1 and PD-L1 in patients.The relationship between serum SIRT1,sICAM-1 and PD-L1 levels and clinical characteristics,treatment efficacy,and prognosis of patients were analyzed.Multiple logistic regression analysis was used to identify the factors that affect the prognosis of refractory DLBCL patients.Receiver operating characteristic(ROC)curve was draw,and the area under the curve(AUC)was calculated,the predictive ability of serum SIRT1,sICAM-1,and PD-L1 levels for the prognosis of refractory DLBCL patients was evaluated.Results The serum levels of SIRT1,sICAM-1 and PD-L1 in patients with poor prognosis were higher than those in patients with good prognosis(P＜0.05).Multivariate logistic regression analysis showed that serum levels of SIRT1,sICAM-1 and PD-L1 were independent risk factors for poor prognosis in refractory DLBCL patients(P＜0.05).The AUC values for predicting poor prognosis in patients with refractory DLBCL using serum SIRT1,sICAM-1,and PD-LI alone or in combination were 0.851,0.843,0.924,and 0.980,respectively.The combined predictive value of these three factors was higher than that of alone(P＜0.05).Conclusion Serum levels of SIRT1,sICAM-1 and PD-L1 can serve as important prognostic indicators for refractory DLBCL patients,and the combined detection of the three is more effective than single detection,which is of great significance for guiding clinical treatment and monitoring disease progression.
silent information regulatory factor 1soluble intercellular adhesion molecule-1programmed cell death-ligand 1refractory diffuse large B-cell lymphomaprognosis
NETL
NSTL
万方数据
