Value of Serum TNF-α and IL-17 Expression in Predicting Residual Pain in Postoperative Patients with Lumbar Disc Herniation
Objective To explore the value of serum tumor necrosis factor(TNF-α)and interleukin-17(IL-17)expression in predicting postoperative residual pain in patients with lumbar disc herniation.Methods Clinical data of 165 patients with lumbar disc herniation admitted to the Second Affiliated Hospital of Zhengzhou University from January 2020 to January 2023 were retrospectively collected.Based on the residual pain situation of the patients at 6 months after surgery,they were divided into a residual pain group(19 cases)and a non-residual pain group(146 cases).Serum TNF-α and IL-17 levels of patients were tested before surgery.The predictive value of serum TNF-α and IL-17 for postoperative residual pain in patients with lumbar disc herniation was analyzed.Results There were differences in fibrous ring injury and the levels of TNF-α and IL-17 between the two groups(P＜0.05).Through logistic regression analysis,the results showed that serum TNF-α,IL-17 levels and annulus fibrosus injury were risk factors for postoperative residual pain in patients with lumbar disc herniation(OR＞1,P＜0.05).The results of drawing receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of serum TNF-α,IL-17,and their combined prediction of postoperative residual pain in patients with lumbar disc herniation were all greater than 0.7,indicating certain predictive value,and the combined predictive value was higher.Conclusion The high expression of serum TNF-α and IL-17 are the influencing factors of postoperative residual pain in patients with lumbar disc herniation,and has certain predictive value.
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