Correlation Between the Expression of IGF-1,β2-MG and HBP in Cerebrospinal Fluid and the Occurrence and Development of Suppurative Meningitis in Children
Objective To explore the correlation of the expression level of insulin-like growth factor-1(IGF-1),β2 microglobulin(β2-MG)and heparin binding protein(HBP)in cerebrospinal fluid and the occurrence and development of suppurative meningitis disease in children.Methods From February 2021 and February 2023,86 children diagnosed with purulent meningitis at the First Affiliated Hospital of Zhengzhou University were selected as the study group,and 86 children with non-central nervous system infection were selected as the control group.The expression of cerebrospinal fluid IGF-1,β2-MG and HBP between the groups were compared,and the correlation with the severity and prognosis in the study group were explored.Results The cerebrospinal fluid levels of IGF-1,β2-MG and HBP in the study group were higher than those in the control group(P＜0.05).And they had high diagnostic value for suppurative meningitis,the area under the curve were 0.925,0.930,and 0.850,respectively.The levels of IGF-1,β2-MG and HBP in the cerebrospinal fluid of the severe group were higher than those of the mild group(P＜0.05).The levels of IGF-1,β2-MG and HBP in cerebrospinal fluid of the poor prognosis group were higher than those of the good prognosis group(P＜0.05).And they had high predictive value for the poor prognosis of suppurative meningitis,the area under the curve were 0.879,0.854,and 0.822,respectively.Conclusion Monitoring the level of IGF-1,β2-MG and HBP in the cerebrospinal fluid of pediatric suppurative meningitis is important for early diagnosis,judging the severity of disease and prediction of disease prognosis.
cerebrospinal fluidinsulin-like growth factor-1β2 microglobulinheparin binding proteinpyogenic meningitis in the children
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