Correlation of Vitamin D Levels with Serum CRP,Autoimmune Antibodies and Thyroid Function in Patients with Type 2 Diabetes
Objective To investigate the correlation between vitamin D levels and serum C-reactive protein(CRP),autoimmune antibodies and thyroid function in patients with type 2 diabetes mellitus.Methods A total of 150 patients with type 2 diabetes treated in the Affiliated Hospital of Xinyang Vocational and Technical College from January 2018 to January 2019 were selected as the study group,and 50 healthy subjects were selected as the control group during the same period.Serum CRP,serum 25-hydroxy vitamin D[25(OH)D],islet autoimmune antibodies and thyroid function indexes were detected and the differences between the two groups were compared.According to the serum 25(OH)D level,the study group was divided into 4 subgroups:normal group(34 cases),insufficient group(37 cases),deficient group(39 cases)and severely deficient group(40 cases).The serum CRP,islet autoimmune antibody positive rate and thyroid function index levels were compared between the groups.The correlation between serum 25(OH)D and CRP,islet autoimmune antibody and thyroid function index was analyzed by Pearson and Spearman correlation analysis.After 3 years of follow-up,the incidence of thyroid dysfunction was analyzed,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of serum 25(OH)D in thyroid dysfunction in type 2 diabetes patients.Results Compared with the control group,the levels of serum 25(OH)D and TSH in the study group were lower,the levels of CRP and the positive rate of islet autoimmunity antibody were higher(P＜0.05).The serum CRP,islet autoimmune antibody positive rates and TSH levels of normal group,deficiency group,deficiency group and severe deficiency group were significantly different,and the serum CRP and TSH levels were gradually increased(P＜0.05).Serum 25(OH)D levels were negatively correlated with CRP(r=-0.714),islet autoimmune antibody positive rate(r=-0.397)and TSH(r=-0.410)levels in patients with type 2 diabetes(P＜0.001).The incidence of thyroid dysfunction in type 2 diabetes patients was 25.33％(38/150),and the AUC of serum 25(OH)D predicted by ROC curve analysis was 0.916.Conclusion Serum vitamin D is negatively correlated with the positive rate of CRP,autoimmune antibody and thyroid function index in patients with type 2 diabetes,and has certain predictive value for the occurrence of thyroid dysfunction.
type 2 diabetes mellitusC-reactive proteinvitamin Dautoimmune antibodiesthyroid function
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