Relationship Between Serum CTGF,PGE2 and Intrauterine Adhesions After Hysteromyoma Resection
Objective To investigate the relationship between serum connective tissue growth factor(CTGF),prostaglandin E2(PGE2)and intrauterine adhesions after hysteromyoma resection.Methods A total of 155 patients who underwent myomectomy in Pingdingshan First People's Hospital from June 2021 to June 2023 were selected as the study objects.All patients were followed up for 6 months.According to whether intrauterine adhesions occurred after operation,the patients were divided into two groups:intrauterine adhesions and non-intrauterine adhesions.The levels of serum CTGF and PGE2 were compared between the two groups,and the influencing factors of intrauterine adhesions after hysteromyoma resection were analyzed by multivariate logistic regression,and the application value of serum CTGF and PGE2 on intrauterine adhesions after hysteromyoma resection was explored by receiver operating characteristic(ROC)curve.Results After 6 months of follow-up,a total of 3 patients were lost to follow-up.Among the 152 patients who underwent myomectomy,45 cases had intrauterine adhesions,the incidence of intrauterine adhesions was 29.61％.There were significant differences in uterine operation history and postoperative drug use between the patients with intrauterine adhesions group and those without intrauterine adhesions group(P＜0.05).The levels of serum CTGF and PGE2 in the group with intrauterine adhesion were higher than those in the group without intrauterine adhesion(P＜0.05).Multivariate logistic regression analysis showed that history of uterine surgery,non-adherence to postoperative medication,serum CTGF and PGE2 levels were all risk factors for intrauterine adhesions after hysteromyoma resection(P＜0.05).The area under curve(AUC)values of serum CTGF and PGE2 levels and their combination for predicting intrauterine adhesion after hysteromyoma resection were 0.784,0.771 and 0.805,respectively,and the specificity were 79.69％,76.24％and 81.45％,respectively.The sensitivity was 78.22％,77.93％and 84.51％,respectively.AUC value,specificity and sensitivity of combined detection were higher than that of single detection(P＜0.05).Conclusion Serum CTGF and PGE2 levels are associated with intrauterine adhesions after hysteromyoma resection,and the combination of these two indexes can help predict the risk of intrauterine adhesions after hysteromyoma resection.
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