Value of Electroencephalography Combined with Serum BNP and NSE in Predicting the Prognosis of Children with Viral Encephalitis
Objective To explore the clinical value of electroencephalography(EEG)combined with serum natriuretic peptide(BNP)and neuron-specific enolase(NSE)in the prognosis of children with viral encephalitis.Methods A total of 89 children with viral encephalitis admitted to Kaifeng Central Hospital from April 2021 to June 2023 were selected for the study.According to the Glasgow prognostic scale,the prognosis of the children was grouped,and there were 29 cases in the good prognosis group(grade 4-5)and 60 cases in the poor prognosis group(grade 1-3).The clinical data,serum BNP,NSE examination and electroencephalogram were compared,the influencing factors affecting the prognosis of children with viral encephalitis were analyzed,and the value of alone and combined in predicting the prognosis in children with viral encephalitis was compared.Results The abnormal rate of EEG and serum BNP and NSE levels in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).The proportion of status convulses in the poor prognosis group was higher than that in the good prognosis group(P＜0.05).Multivariate logistic regression showed that moderate and severe abnormalities in EEG,serum BNP,serum NSE and status convulsive status were risk factors for the prognosis of children with viral encephalitis(P＜0.05).The area under the curve(AUC)of EEG,NSE and BNP was 0.971,sensitivity was 98.30％and specificity was 93.10％,which was greater than the single test.Conclusion Moderate and severe abnormalities in EEG,serum BNP and NSE are risk factors for the prognosis of children with viral encephalitis,and the prognostic value of combined assessment is higher than that of single assessment.
electroencephalogrambrain natriuretic peptideneuron specific enolaseviral encephalitischildprognosis
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