Effect of PD-1 Inhibitor and Anti-angiogenic Drug Combined with TACE in the Treatment of Primary Liver Cancer
Objective To investigate the efficacy of programmed death receptor-1(PD-1)inhibitors and anti-angiogenic drugs combined with transarterial chemoembolization(TACE)in the treatment of primary liver cancer.Methods Fifty-eight patients with primary liver cancer were included,all of whom were treated in Henan Cancer Hospital from January 2019 to December 2022 and the patients were divided into control group(anti-angiogenic drug combined with TACE treatment,30 cases)and study group(PD-1 inhibitor combined with anti-angiogenic drug combined with TACE treatment,28 cases)according to treatment methods.The two groups were treated for 9 weeks,and the efficacy,liver function[alkaline phosphatase(ALP),alanine transaminase(ALT),aspartate transaminase(AST),total bilirubin(TBIL)],vascular endothelial growth factor(VEGF),soluble vascular cell adhesion molecule 1(s VC AM1),immune indexes and adverse reactions were compared.Results The disease control rate of the study group(85.71％)was higher than that of the control group(60.00％)(P＜0.05).After treatment,ALP,ALT,AST and TBIL in two groups were lower than before treatment,and the study group was lower than the control group(P＜0.05).VEGF and s VC AM1 were lower in two groups after treatment than before treatment,and the study group was lower than the control group(P＜0.05).After treatment,CD3+,CD4+and CD8+were higher than before treatment,and CD4+/CD8+was lower than before treatment,and the study group was better than the control group(P＜0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P＞0.05).Conclusion PD-1 inhibitors and anti-angiogenic drugs combined with TACE are effective in the treatment of primary liver cancer,which can reduce liver injury and improve immune function in patients with good safety.
primary liver cancerprogrammed death receptor-1 inhibitortransarterial chemoembolizationanti-angiogenic drug
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