Objective To observe the difference of evoked cortical potential(CAEP)in children with cochlear implant with different deaf-inducing gene mutations.Methods The clinical data of 32 children with no residual hearing and SLC26A4 gene,GJB2 gene or TMPRSS3 gene mutation who underwent unilateral cochlear implantation(CI512)in the Department of Otology of the First Affiliated Hospital of Zhengzhou University were analyzed and divided into A,B and C groups.CAEP detection was performed under/ba1/and/ba4/acoustic stimulation one month after surgery,respectively,and P1 wave extraction rate,latency and amplitude were recorded under/ba1/and/ba4/acoustic stimulation.Results There was no significant difference in extraction rate between groups A and B under acoustic stimulation of/ba1/and/ba4/(P＞0.05).The extraction rate of groups A and B was higher than that of group C,and the difference was statistically significant(P＜0.05).There was no significant difference in latency between groups A and B under acoustic stimulation(P＞0.05).The incubation period of groups A and B was shorter than that of group C(P＜0.05).There was no significant difference in amplitudes between groups A,B and C under acoustic stimulation(P＞0.05).Conclusion The P1 wave extraction rate of CAEP with SLC26A4 gene and GJB2 gene mutation is higher than that of TMPRSS3 gene mutation,and the P1 wave latency of CAEP with LC26A4 gene and GJB2 gene mutation is shorter than that of TMPRSS3 gene mutation.
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万方数据