Clinical Comparison of Different Mechanical Ventilation Schemes Combined with Dobutamine in the Treatment of Persistent Pulmonary Hypertension of the Newborn
Objective To compare the clinical effect of different mechanical ventilation schemes combined with dobutamine in persistent pulmonary hypertension of the newborn(PPHN).Methods A total of 82 neonates with PPHN treated in the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2022 were selected,using computer-generated random numbers to divide them into two groups,with 41 cases in each group.Both groups received routine treatment,the control group was treated with normal frequency mechanical ventilation combined with dobutamine,and the observation group was treated with high frequency oscillatory ventilation combined with dobutamine,both groups were treated for 2 days.The clinical efficacy,blood gas analysis indexes and related serum indexes[N-terminal pro-brain natriuretic peptide(NT-proBNP)and creatine kinase isoenzymes(CK-MB)]were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).The arterial partial pressure of oxygen(PaO2)and arterial oxygen saturation(SaO2)of patients in both groups were increased and arterial partial pressure of carbon dioxide(PaCO2)was decreased two days after treatment,and PaO2 and SaO2 in the observation group were higher than those in the control group,while PaCO2 was lower than that in the control group(P＜0.05).Compared with before treatment,the NT-proBNP and CK-MB levels in the two groups of children decreased after 2 days of treatment,and the NT-proBNP and CK-MB levels in the observation group were lower than those in the control group(P＜0.05).Conclusion High frequency oscillatory ventilation combined with dobutamine has definite efficacy in the treatment of PPHN,which can improve the indexes of blood gas analysis and reduce myocardial injury.
persistent pulmonary hypertension of the newbornmechanical ventilationdobutamineblood gas analysis
万方数据
维普
