Correlation Between Serum PDCD5,CYFRA21-1 and Poor Prognosis After Laparoscopic Radical Gastrectomy for Gastric Cancer
Objective To explore the correlation between serum programmed cell apoptosis factor 5(PDCD5),cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and poor prognosis after laparoscopic radical gastrectomy.Methods A retrospective analysis was conducted to collect data from 95 gastric cancer patients who underwent concurrent laparoscopic radical gastrectomy at Tumor Hospital Xinyang from January 2020 to January 2021.The patients with recurrence within 3 years after operation were included in the poor prognosis group(31 cases),and the patients without recurrence were included in the good prognosis group(64 cases).The baseline data of patients with different prognosis and the levels of serum PDCD5 and CYFRA21-1 before radical operation were compared,and the relationship between serum PDCD5 and CYFRA21-1 and the poor prognosis of patients with gastric cancer after laparoscopic radical gastrectomy was analyzed.Results The preoperative serum levels of PDCD5 and gastrin-17(G-17)in the poor prognosis group were lower than those in the good prognosis group,while the serum levels of CYFRA21-1,carcinoembryonic antigen(CEA)and alpha-fetoprotein(AFP)were higher than those in the good prognosis group(P＜0.05).The results of Cox survival regression analysis showed that poor prognosis in gastric cancer patients may be related to abnormal levels of serum PDCD5,G-17,CYFRA21-1,CEA and AFP at admission(P＜0.05).There was a negative interaction between serum PDCD5 and CYFRA21-1 on the occurrence of poor prognosis in patients with gastric cancer.The risk of poor prognosis when serum PDCD5 was low and CYFRA21-1 was high was 103.714 times that of serum PDCD5 was high and CYFRA21-1 was low.Conclusion The risk of poor prognosis in patients undergoing laparoscopic radical gastrectomy may be related to the abnormal levels of preoperative serum PDCD5 and CYFRA21-1,which should be paid attention to in clinical practice.
万方数据
维普
