Value of Magnetic Resonance Imaging Parameters Combined with Tumor Markers in the Diagnosis of Ovarian Tumors
Objective To investigate the value of magnetic resonance imaging(MRI)parameters combined with serum tumor markers in the diagnosis of ovarian tumors.Methods A total of 113 patients with ovarian tumor who were treated in Kaifeng Cancer Hospital from July 2021 to May 2023 were selected as the study objects,70 patients with benign tumor(benign group)and 43 patients with malignant tumor(malignant group)were pathologically confirmed.All subjects underwent MRI and tumor markers such as serum carbohydrate antigen 125(CA1 25),human epididymis protein 4(HE4),and alpha-fetoprotein(AFP)were detected.Sensitivity,specificity and area under the curve(AUC)area of receiver operating characteristic(ROC)curve were used to evaluate the diagnostic value of single and combined tests for ovarian tumors.Results The maximum tumor diameter in the malignant group was higher than that in the benign group,the apparent diffusion coefficient(ADC)value was lower than that in the benign group,and the proportion of unclear boundary,irregular shape,solid or cystic components and enhancement degree was higher than that in the benign group,and the diagnostic positive rate of serum CA125,HE4 and AFP tumor markers was higher than that in the benign group,with statistical significance(P＜0.05).The sensitivity of MRI and tumor markers was 62.79％-81.40％,and the AUC area was 0.743-0.878.The sensitivity and AUC area of MRI+CA125+HE4 were the highest,which were 97.67％and 0.938,respectively.Conclusion There are significant differences in MRI parameters and serum CA125,HE4 and AFP tumor markers between benign and malignant ovarian tumors.MRI combined with serum CA125 and HE4 has important clinical value in the differential diagnosis of ovarian tumors.
magnetic resonance imagingtumor markerovarian tumorcombined detection
万方数据
维普
