Correlation of Serum IGF-1,IL-18 and Radiosensitivity in Patients with Esophageal Cancer
Objective To explore and analyze the correlation between serum insulin like growth factor 1(IGF-1),interleukin-18(IL-18)and radiosensitivity in esophageal cancer patients.Methods Retrospective analysis was conducted to collect data from 98 esophageal cancer patients who underwent radiotherapy at the Second People's Hospital of Jiaozuo from January 2021 to December 2022.All patients received radiotherapy,and radiosensitivity was evaluated one week after the end of radiotherapy.Patients were grouped according to radiosensitivity,and demographic and clinical data were recorded.The correlation between IGF-1,IL-18 and radiosensitivity before radiotherapy was mainly analyzed in both groups of patients.Results Among all 98 patients,65 cases(66.33％)were sensitive to radiotherapy.There were statistical differences in tumor staging,tumor differentiation,and metastasis between the radiation sensitive group and the radiation insensitive group(P＜0.05).The expression of serum IGF-1 and IL-18 levels before radiotherapy in the insensitive group were higher than those in the sensitive group(P＜0.05).Two column correlation test showed a positive correlation between the expression of serum IGF-1 and IL-18 levels before radiotherapy and radiosensitivity in esophageal cancer(r＞0,P＜0.05).According to the restricted cubic spline model(RCS)analysis,the correlation between serum IGF-1 and IL-18 before radiotherapy and the risk of radiation insensitivity in esophageal cancer showed a nonlinear J-type dose-response relationship.When serum IGF-1 and IL-18 were greater than the cut off value,the risk of patient insensitivity increased with the increase of indicator levels.Conclusion There is a positive correlation between serum IGF-1 and IL-18 levels before radiotherapy and radiosensitivity in esophageal cancer patients,indicating that high levels of IGF-1 and IL-18 levels before radiotherapy may indicate a high risk of radiotherapy insensitivity and should be taken seriously.
万方数据
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