Effects of Shuxuening Injection Combined with Celecoxib on Hemodynamics and Serum ET-1 and NO Levels in Patients with Vertebral Artery Type Cervical Spondylosis
Objective To observe the clinical efficacy of Shuxuening injection combined with celeoxib in the treatment of vertebral artery type cervical spondylosis of vertebral artery type(CSA),and to explore its influence on hemodynamics and vascular endothelial function.Methods A total of 90 patients with CSA admitted to the First Affiliated Hospital of Henan University of Science and Technology from June 2019 to June 2022 were selected as the study objects,45 of whom were treated with celecoxib(set as control group)and 45 with Shuxuening injection combined with celecoxib(set as study group).After 10-12 days of treatment,the therapeutic effect and adverse reactions were compared between the two groups.Range of motion(ROM),evaluation scale for cervical vertigo(ESCV),neck disability index(NDI),hemodynamics[time-mean flow velocity(TMFV),peak systolic blood flow velocity(PSV),pulse index(PI),resistance index(RI)]and vascular endothelial function[endothelin-1(ET-1),nitric oxide(NO),thromboxane A2(TXA2)]were compared between the two groups before and after treatment.Results Compared with the control group,the total effective rate of the study group was significantly increased(P＜0.05).Compared with the control group,the ROM score and NDI score of the study group were decreased after treatment,and the ESCV score was increased(P＜0.05).Compared with the control group,TMFV and PSV were increased and PI and RI were decreased in the study group after treatment(P＜0.05).Compared with the control group,the serum levels of ET-1 and TXA2 in the study group were decreased after treatment,while the level of NO was increased(P＜0.05).There were no serious adverse reactions in both groups.Conclusion Shuxuening injection combined with celecoxib is effective,safe and reliable in the treatment of CSA,which can improve cervical motion,cervical function and hemodynamics,promote the recovery of vascular endothelial function.
vertebral artery type cervical spondylosisShuxueningcelecoxibhemodynamicsvascular endothelial function
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