Effect of Domestic Rapamycin Drug-Eluting Stents and Paclitaxel Drug-Eluting Balloons on the Recent Prognosis in Patients with Coronary Heart Disease
Objective To explore the impact of domestic rapamycin drug-eluting stent and paclitaxel drug-eluting balloon on the recent prognosis of percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods The study included coronary heart disease patients treated with interventional procedures at the First Affiliated Hospital of Xinxiang Medical University from March 2020 to March 2021.Fifty-six patients who received domestic rapamycin drug-eluting stents were retrospectively selected as the drug-eluting stent group,while fifty-seven patients who underwent paclitaxel drug-eluting balloon angioplasty were chosen as the drug-eluting balloon group.Both groups were followed up for one year.Preoperative and one-week postoperative indicators of heart rate variability,coronary angiography parameters,target lesion luminal diameter,and narrowing,as well as serum levels of kallikrein-1(KLK1),tissue inhibitor of metalloproteinases-1(TIMP-1),endothelin-1(ET-1),and nitric oxide(NO)were compared.The incidence of adverse cardiovascular events within one year after the procedure was compared.Results There were no differences between the two groups in the standard deviation of NN intervals(SDNN),standard deviation of the average of NN intervals(SDANN),percentage of differences between adjacent NN intervals greater than 50 ms(pNN50),reference vessel diameter of target lesion,minimum lumen diameter and diameter stenosis rate before and 1 week after operation(P＞0.05).At 1 week after operation,the SDNN,SDANN,pNN50 and minimum lumen diameter of target lesion in the two groups were higher than those before operation(P＜0.05),the diameter stenosis rate was significantly lower than that before operation(P＜0.05),and the reference vessel diameter of target lesion was unchanged compared with that before operation(P＞0.05).Before operation,there were no differences in KLK1,TIMP-1,ET-1 and NO levels between the two groups(P＞0.05).At 1 week after operation,KLK1 and NO levels in the two groups were higher than those before operation,and those in the study group were higher than those before operation,and TIMP-1 and ET-1 levels were lower than those before operation,and those in the study group were lower than those before operation(P＜0.05).There was no difference in the incidence of adverse cardiovascular events between the two groups during the follow-up period(P＞0.05).Conclusion When treating PCI in patients with coronary heart disease,the effect of using domestic rapamycin drug-eluting stent and paclitaxel drug-eluting balloon is similar in recent outcomes and do not increase the risk of poor prognosis.
万方数据
维普
