Influencing Factors of Adrenal Insufficiency After Laparoscopic Unilateral Adrenalectomy
Objective To investigate the influencing factors of adrenal insufficiency(AI)after laparoscopic unilateral adrenalectomy.Methods A total of 100 patients with laparoscopic unilateral adrenalectomy admitted to Xinxiang Central Hospital from January 2018 to December 2021 were collected as the study objects.The patients were divided into AI group and non AI group according to their plasma cortisol concentration after operation.The data that may lead to AI before and during the operation were collected.The risk factors of AI after laparoscopic unilateral adrenalectomy were analyzed by single factor and multiple factor logistic regression.The predictive value of risk factors for AI after laparoscopic unilateral adrenalectomy was analyzed by drawing the receiver operating characteristic(ROC)curve.Results Compared with that before operation,the plasma cortisol concentration of patients in this group immediately increased after operation and 6 hours after operation(P＜0.05),and decreased and recovered 12-72 hours after operation,but there was no statistical significance compared with that before operation(P＞0.05).Compared with the non AI group,the patients in the AI group were older,the levels of serum C-reactive protein(CRP)and interleukin-6(IL-6)were lower(P＜0.05).Multivariate logistic regression analysis showed that old age,high serum CRP and IL-6 levels were independent risk factors for AI after laparoscopic unilateral adrenalectomy.The area under the curve(AUC)of AI after laparoscopic unilateral adrenalectomy predicted by age,serum CRP and IL-6 levels alone or jointly was 0.661,0.681,0.684,0.739,and the AUC predicted jointly was the largest.Conclusion Old age,high serum CRP and IL-6 levels are independent risk factors of AI after laparoscopic unilateral adrenalectomy,and they have certain predictive value for the risk of AI and the combination of them has the highest predictive effect.
laparoscopic unilateral adrenalectomyadrenal insufficiencycortisolrisk factorpredictive value
万方数据
维普
