Predictive Value of Serum SAA/CRP for Prosthetic Joint Infection After Hip and Knee Replacement Surgery
Objective To explore the predictive value of serum amyloid A(SAA)/C-reactive protein(CRP)for prosthetic joint infection(PJI)after hip and knee replacement surgery.Methods A retrospective analysis was conducted on the data of 1 158 patients who underwent hip or knee replacement surgery in Anyang People's Hospital from January 2017 to December 2022.And 27 patients with postoperative PJI were included in the infected group.After calculating the sample size of the control group using the sample calculation formula,127 eligible patients were selected from 1 131 patients who did not experience PJI and included in the uninfected group.The baseline data questionnaire was designed to collect the required data.The serum SAA and CRP levels were recorded and compared before operation and on the first day after operation,and the SAA/CRP ratio was calculated.The predictive value of serum SAA/CRP for PJI after hip and knee arthroplasty was analyzed.Results The proportion of diabetes,smoking history and preoperative anemia in the infected group were higher than those in the uninfected group(P＜0.05).The serum levels of SAA,CRP and SAA/CRP in both groups increased on the 1st day after surgery compared to preoperative levels,and the levels of SAA and SAA/CRP in the infected group were higher than the uninfected group(P＜0.05).There was no statistical difference in serum CRP levels between the two groups on the 1 st day after surgery(P＞0.05).The receiver operating characteristic curve was drawn,and the results showed that the area under the curve of SAA and SAA/CRP for predicting PJI after hip and knee replacement surgery were 0.711 and 0.866,respectively.The predictive value of SAA/CRP was better than SAA(x2=6.932,P＜0.001).Conclusion The serum SAA/CRP ratio in PJI patients is upregulated after hip and knee replacement surgery,and this abnormal upregulation has ideal predictive value for the occurrence of postoperative PJI.
hip and knee joint replacement surgeryprosthetic joint infectionserum amyloid protein AC-reactive protein
万方数据
维普
