Clinical Effects of Feneridone Combined with Sigliptin in the Treatment of Diabetic Nephropathy
Objective To explore the effect of combination of fenelidone and sitagliptin in the treatment of diabetes nephropathy(DN).Methods A total of 75 patients with DN who admitted to the General Hospital of Hebi Coal Industry(Group)Co.,LTD.from July 2022 to July 2023 were divided into control group(37 cases)and observation group(38 cases)by random number table method.The control group received treatment with sitagliptin,while the observation group received additional treatment with phenirazone in addition to the control group.Both groups were treated continuously for 3 months.Renal function and blood glucose control before and after treatment were compared.The occurrence of adverse reactions to two groups of drugs during the treatment period were recorded.Results After treatment,the levels of serum creatinine(SCr),cystatin C(CysC),blood urea nitrogen(BUN),and urinary albumin creatinine ratio(ACR)decreased in both groups,and compared to the control group,the observation group were lower(P＜0.05).After treatment,postprandial blood glucose levels decreased in both groups,and the observation group was lower than the control group(P＜0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of fenalidomide and sigliptin can effectively improve renal function in DN patients,help patients better control blood sugar,and do not increase adverse drug reactions,with definite therapeutic effects.
万方数据
维普
