Correlation Between METS-IR and Stroke Occurrence in Middle-Aged and Elderly Hypertensive Patients
Objective To analyze the correlation between metabolic score for insulin resistance(METS-IR)and stroke in middle-aged and elderly hypertensive patients.Methods This study screened 849 hypertensive patients admitted to the Cardiovascular Department of the First Affiliated Hospital of Zhengzhou University from June 2022 to November 2023.Based on their medical history and head magnetic resonance imaging(MRI)and magnetic resonance angiography(MRA),they were divided into a stroke group(482 cases)and a control group(367 cases).Logistic regression analysis was applied to investigate the correlation between METS-IR levels and disease risk.Results Single factor logistic regression analysis showed that the smoking history,body mass index(BMI),systolic blood pressure(SBP),fasting blood glucose(FBG),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and homocysteine(HCY)in the stroke group were higher than those in the control group,and the differences were statistically significant(P＜0.05).In the multiple logistic regression analysis model,after adjusting for relevant confounding factors,subjects in the highest quartile of METS-IR had a 93％increased risk of disease compared to those in the lowest quartile of METS-IR(P=0.031).The area under the receiver operating characteristic(ROC)curve was 0.798,and the optimal critical value for METS-IR was 39.89.Conclusion Elevated METS-IR is associated with stroke in middle-aged and elderly hypertensive patients,and is an independent risk factor with certain predictive value.As METS-IR levels increase,the risk of stroke increases.
metabolic score for insulin resistancehypertensionstrokeinsulin resistance
万方数据
维普
