Relationship of Serum Uric Acid、Cystatin C and Alkaline Phosphatase Levels with Post-stroke Depression
Objective To analyze the relationship of serum uric,acid,cystatin C(Cys C)and alkaline phosphatase levels after post-stroke depression(PSD).Methods The clinical data of 202 patients with acute stroke diagnosed and treated in the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively,and their condition was stable after neurological treatment.The patients were divided into depression group(105 cases)and control group(97 cases)according to Hamilton depression rating scale(HAMD)score.The general clinical data and laboratory data of the two groups were collected,and the risk factors for PSD in acute stroke patients were analyzed by logistic regression.The clinical value of serum uric acid and Cys C levels in predicting PSD was analyzed according to the receiver operating characteristic(ROC)curve.Results There were no statistically significant differences between the two groups in terms of gender,hypertension,diabetes mellitus,diabetes mellitus,smoking,alcohol consumption,coronary heart disease,history of atrial fibrillation,incidence type,time from onset to hospital admission and serum alkaline phosphatase levels(P＞0.05).There were significant differences between the PSD group and the control group in terms of advanced age,National Institute of Health stroke scale(NIHSS)score,serum uric acid and Cys C levels(P＜0.05).Logistic regression analysis suggested that serum uric acid level and Cys C level were the influencing factors for PSD in patients with acute stroke.The most critical value of serum uric acid concentration for predicting PSD was 317.251 μmol·L-1.The optimal cut-off value for serum Cys C concentration to predict PSD was 2.155 mg·L-1.Conclusion There was no correlation between serum alkaline phosphatase levels and the development of PSD.Serum uric acid and Cys C levels are influencing factors for the development of PSD in patients with acute stroke,and their serum levels have high diagnostic value for the development of PSD in patients with acute stroke,and can be used as a serologic indicator to predict the occurrence of PSD.
万方数据
维普
