首页|肺炎支原体肺炎患儿气道黏液栓形成风险的列线图模型构建

肺炎支原体肺炎患儿气道黏液栓形成风险的列线图模型构建

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目的 对肺炎支原体肺炎(MPP)患儿气道黏液栓形成的因素进行分析,并构建列线图模型.方法 回顾性收集2021年1月至2022年12月濮阳市人民医院收治的118例MPP患儿临床资料,依据纤维支气管镜检查下是否形成气道黏液栓分为无黏液栓组(78例)和黏液栓组(40例).比较两组临床资料,分析并构建MPP患儿形成气道黏液栓的风险预测模型,利用R软件构建列线图,对其区分度和准确度做内部验证.结果 与无黏液栓组比较,黏液栓组热程、中性粒细胞、乳酸脱氢酶、C反应蛋白、胸腔积液比率均较高,差异有统计学意义(P<0.05);经logistic回归分析结果显示,MPP患儿气道黏液栓形成的影响因素为热程、中性粒细胞、乳酸脱氢酶、C反应蛋白、胸腔积液(OR>1,P<0.05);绘制列线图构建MPP患儿气道黏液栓形成的风险预测模型,显示该模型具有良好的区分度(C-index为0.993);绘制标准曲线显示,模型准确度良好(校准曲线和Y-X直线相近).结论 MPP患儿气道黏液栓形成的因素包括中性粒细胞、乳酸脱氢酶、C反应蛋白、胸腔积液、热程,且基于上述因素构建的MPP患儿气道黏液栓形成的风险预测模型具有一定预测价值.
Construction of a Column Chart Model for the Risk of Airway Mucus Embolism Formation in Children with Mycoplasma Pneumoniae Pneumonia
Objective To analyze the factors contributing to the formation of airway mucus plugs in children with Mycoplasma pneumoniae pneumonia(MPP)and construct a column chart model.Methods Clinical data of 118 children with MPP admitted to Puyang People's Hospital from January 2021 to December 2022 were retrospectively collected.According to whether airway mucus plugs were formed under fiberoptic bronchoscopy,they were divided into non-mucus plug group(78 cases)and mucus plug group(40 cases).The clinical data of the two groups were compared.A risk prediction model for the formation of airway mucus plugs in children with MPP was analyzed and constructed.The nomogram was constructed by R software,and its discrimination and accuracy were internally verified.Results Compared with the non-mucous plug group,the proportion of fever,neutrophils,lactate dehydrogenase,C-reactive protein and pleural effusion in the mucus plug group were higher(P<0.05).The results of logistic regression analysis showed that the influencing factors of airway mucus clot formation in MPP children were heat stroke,neutrophils,lactate dehydrogenase,C-reactive protein,and pleural effusion(OR>1,P<0.05).A column chart was drawn to construct a risk prediction model for airway mucus clot formation in MPP children,which showed good discrimination(C-index was 0.993).Standard curve was drawn to show that the model had good accuracy(the calibration curve was similar to the Y-X line).Conclusion The factors of airway mucus plug formation in children with MPP include neutrophils,lactate dehydrogenase,C-reactive protein,pleural effusion,and thermal process,and the risk prediction model of airway mucus plug formation in children with MPP based on the above factors has certain predictive value.

Mycoplasma pneumoniae pneumoniachildrenairway mucus plugcolumn chart model

时利玲、张俊霞、梁娟、张敬芳

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濮阳市人民医院儿科,河南濮阳 457000

肺炎支原体肺炎 小儿 气道黏液栓 列线图模型

2021年度河南省医学科技攻关计划

LHGJ20210932

2024

河南医学研究
河南省医学科学院

河南医学研究

影响因子:0.979
ISSN:1004-437X
年,卷(期):2024.33(19)