Value of FA,Betatrophin and YKL-40 in Predicting Rebleeding After Neuroendoscopy in Hypertensive Deep Intracerebral Hemorrhage
Objective To investigate the efficacy of serum fetuin-A(FA),angiopoietin-like protein betatrophin and chitinase protein-40(YKL-40)in predicting rebleeding after neuroendoscopy for hypertensive deep intracerebral hemorrhage.Methods A total of 169 patients with hypertensive deep intracerebral hemorrhage in Neurosurgery Department,the Second People's Hospital of Jiaozuo from September 2019 to September 2021 were selected,all of whom underwent neuroendoscopy successfully.In the bleeding group,the general data of the two groups were compared with the preoperative and postoperative serum FA,betatrophin,YKL-40 and the difference between the three before and after the operation,and the related data were statistically analyzed.Results The rebleeding group had more hematoma volume,application of anticoagulant drugs and brain herniation than the non-rebleeding group,and the GCS score at admission was lower than that of the non-rebleeding group(P＜0.05).Serum FA,betatrophin,YKL-40 were higher than those in the non-rebleeding group(P＜0.05).The difference between hematoma volume,application of anticoagulants,cerebral hernia,GCS score at admission,serum FA,betatrophin and YKL-40 surgery were all related to postoperative rebleeding(P＜0.05).The areas under the receiver operating characteristic curve of serum FA,betatrophin and YKL-40 predicted rebleeding were 0.748,0.779 and 0.788,respectively.The area of combination of the three was 0.938;the risk of rebleeding when the difference between serum FA,betatrophin and YKL-40 before and after operation was greater than or equal to the corresponding optimal cut-off value were 4.412,7.464,and 6.033 times less than the corresponding cut-off value,respectively.Conclusion Serum FA,betatrophin and YKL-40 are related to rebleeding after neuroendoscopy in hypertensive deep intracerebral hemorrhage.Monitoring the changes of each index before operation and immediately after operation can help predict the risk of postoperative rebleeding in patients,which is the clinical treatment provide references.
fetuinbetatrophinchitinase protein-40hypertensive deep intracerebral hemorrhageneuroendoscopyrebleeding
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维普
